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RESEARCH OVERVIEW
“A novel protective role for PPARg in stopping the growth and spread of tumours”
One in 28 Canadian women will die from the growth and spread (progression) of breast cancer, resulting from genetic and environmental risk factor interactions. We showed that turning on the protein peroxisome proliferator-activated receptor (PPAR)g stops chemical-induced breast tumour progression. We are now focused on using state-of-the-art methods to definitively show how PPARg stops breast tumourigenesis at the genetic, cellular and whole body levels, and whether natural or synthetic PPARg activators may be novel chemotherapeutic drugs. We also aim to identify individuals at increased breast cancer risk, and improve the clinical effectiveness of therapeutic approaches in susceptible populations. |
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