RESEARCH OVERVIEW

“Regulation of mitosis”

Eukaryotic cells have conserved pathways that regulate entry into and execution of mitosis. These pathways include machinery for activating the cdk/cyclin complex as well as checkpoint and stress responsive pathways to inhibit or delay the process.  This integrative control is essential for genomic stability and successful cell duplication. We use fission yeast as a model genetic system to investigate these pathways, with a focus on the regulatory phosphorylation and dephosphorylation of p34 Cdc2 by the tyrosine phosphatases (Cdc25 and Pyp3) and the tyrosine kinases (Wee1 and Mik1).  All projects have genetics components coupled with molecular and microscopy based approaches.

CONTACT

Tel: (613) 533-6148
Fax: (613) 533-6617
Email: Paul.young (at)queensu.ca
Office: Biosciences Complex 2443

PUBLICATIONS

link to PUBMED .