Department of Pathology

Welcome to the Lab of
Dr. Harriet Feilotter
in Department of Pathology at Queen's University

Page Last Updated: 2012 January 26

Contact Info:

  • Email: hf4 (at) queensu (dot) ca
  • Website:
  • Office Phone: 613-533-6000 x75796

    Research Interests:

    My research focuses on the development of novel diagnostic tools to be used in the screening, diagnosis or treatment of cancer. In many cases, tumours derived from the same cells appear identical when viewed at the cellular level. However, such identical looking tumours often display very different behaviours with respect to long-term outcome or response to therapy. In a clinical setting, it would be important to know as early as possible the likely behaviour of a particular tumour so that treatment can be tailored accordingly. In my lab, we use high throughput methods such as gene expression profiling using microarrays to try to differentiate tumour subgroups at the molecular level that correlate with behaviour or outcome.
    Current projects include the use of a combination of gene expression microarrays, cytogenetics, immunohistochemistry and clinical parameters in the development of a tool for predicting behaviour of follicular lymphoma. As well, we are using cDNA microarrays to identify novel markers specific for prostate cancer progression, for determining BRCA1/BRCA2 status, and are carrying out research into the scope of biological materials that can be used in a microarray-based experiment.

  • Selected publications:

  • Speevak, M.D., Young, S.S., Feilotter, H. and Ainsworth, P. Alternatively spliced, truncated human BRCA2 isoforms contain a novel coding exon. Submitted Eur. J. Hum. Genet.
  • Ozcelik, H., Knight, J., Glendon, G., Carson, N., Ainsworth, P., Feilotter, H., Taylor, S., Carter, R., Boyd, N. and Andrulis, I. Individual and family characteristics associated with BRCA1 and BRCA2 mutations in an Ontario population-based series from the cooperative family registry for breast cancer studies. In press. J. Med. Genet.
  • Feilotter, H.E., Coulon, V., McVeigh, J.L., Boag, A.H., Dorion-Bonnet, F., Duboue, B., Latham, W.C.W., Eng, C., Mulligan, L.M. and Longy, M. 1999. Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma. Br. J. Can. 79: 718-723.
  • Feilotter, H.E., Nagai, M.A., Boag, A.H., Eng, C. and Mulligan, L.M. 1998. Analysis of PTEN and the 10q23 region in primary prostate carcinoma. Oncogene 16: 1743-1748.

    For comments, questions, corrections, etc contact: kellk (at)

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    Queen's University Department of Pathology and Molecular Medicine