Welcome to the Lab of
Page Last Updated: 2012 January 26
Dr. Harriet Feilotter
in Department of Pathology at Queen's University
Email: hf4 (at) queensu (dot) ca
Office Phone: 613-533-6000 x75796
My research focuses on the development of novel diagnostic tools to be used
in the screening, diagnosis or treatment of cancer. In many cases,
tumours derived from the same cells appear identical when viewed at
the cellular level. However, such identical looking tumours often display
very different behaviours with respect to long-term outcome or response
to therapy. In a clinical setting, it would be important to know as early
as possible the likely behaviour of a particular tumour so that treatment
can be tailored accordingly. In my lab, we use high throughput methods
such as gene expression profiling using microarrays to try to differentiate
tumour subgroups at the molecular level that correlate with behaviour or
Current projects include the use of a combination of gene expression
microarrays, cytogenetics, immunohistochemistry and clinical parameters
in the development of a tool for predicting behaviour of follicular
lymphoma. As well, we are using cDNA microarrays to identify novel markers
specific for prostate cancer progression, for determining BRCA1/BRCA2
status, and are carrying out research into the scope of biological
materials that can be used in a microarray-based experiment.
Speevak, M.D., Young, S.S., Feilotter, H. and Ainsworth, P. Alternatively spliced, truncated human BRCA2 isoforms contain a novel coding exon. Submitted Eur. J. Hum. Genet.
Ozcelik, H., Knight, J., Glendon, G., Carson, N., Ainsworth, P., Feilotter, H., Taylor, S., Carter, R., Boyd, N. and Andrulis, I. Individual and family characteristics associated with BRCA1 and BRCA2 mutations in an Ontario population-based series from the cooperative family registry for breast cancer studies. In press. J. Med. Genet.
Feilotter, H.E., Coulon, V., McVeigh, J.L., Boag, A.H., Dorion-Bonnet, F., Duboue, B., Latham, W.C.W., Eng, C., Mulligan, L.M. and Longy, M. 1999. Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma. Br. J. Can. 79: 718-723.
Feilotter, H.E., Nagai, M.A., Boag, A.H., Eng, C. and Mulligan, L.M. 1998. Analysis of PTEN and the 10q23 region in primary prostate carcinoma. Oncogene 16: 1743-1748.
For comments, questions, corrections, etc contact:
kellk (at) queensu.ca
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Queen's University Department of Pathology and Molecular Medicine