Pathology Department Logo Queen's University Logo
Dr. Sandip SenGupta, MD


Professor, Queen's University
Dept. of Pathology and Molecular Medicine

BACKGROUND


Dr. Sandip SenGupta completed his undergraduate medical education at the University of Ottawa (1983) and his postgraduate medical education (in General Pathology) at Queen’s and has been a full time faculty member in the Faculty in Health Sciences since 1988. He holds a cross-appointment in the Department of Oncology (since 2012).

Dr. SenGupta has a unique background of professional experience as both a generalist and a subspecialist in Laboratory Medicine and Pathology/Oncology. In addition to his primary clinical and academic roles at Queen’s, he has served intramurally and extramurally in appointed and elected offices, including as President of the KGH-HDH Medical Staff Association, President of the Ontario Association of Pathologists, and President of the Canadian Association of Pathologists. Currently he is the Chair of the Breast National Cancer Pathology and Staging Multidisciplinary Expert Panel at the Canadian Partnership Against Cancer.

CLINICAL FOCUS

  • surgical pathology of breast diseases, focused on diagnostic oncology, including breast cancer biomarker validation, interpretation, and quality assurance
  • surgical pathology of musculoskeletal disorders and soft tissue tumours
  • regional laboratory outreach program development
  • quality improvement, quality design, patient safety, and utilization management in laboratory medicine

    RESEARCH FOCUS

  • The identification and validation of prognostic and predictive tissue-based biomarkers for the optimal management of breast cancer patients.
  • Multi-institutional breast cancer studies: molecular epidemiology, DCIS, HER-2/neu

    HONOURS AND AWARDS

  • Canadian Certified Physician Executive (2011)
  • Strathmore’s Who’s Who “Professional of the Year” for Healthcare, Education and Diagnosis (2012)
  • “Top Pathologist” of “The Leading Physicians of the World” (2013)

    SELECTED PUBLICATIONS

  • 1. Bhardwaj B, Klassen J, Cossette N, Sterns E, Tuck A, Deeley R, SenGupta SK, Elliott B. Localization of Platelet-Derived Growth Factor Beta Receptor Expression in the Peri-Epithelial Stroma of Human Breast Carcinoma. Clinical Cancer Research; Vol. 2, 773-782, 1996.
  • 2. SenGupta SK, More D, Manley PN. Integrating Academic and Community Laboratory Needs: Developing a Successful Outreach Program. Clinical Laboratory Management Review. 11(1):33-8.
  • 3. Aronson KJ, Miller AB, Woolcott CG, Sterns EE, McCready DR, Lickley LA, Fish EB, Hiraki GY, Holloway C, Ross T, Hanna WM, SenGupta SK, Weber JP. Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk. Cancer Epidemiology, Biomarkers and Prevention; 01; 9(1):55-63, 2000.
  • 4. More D, SenGupta SK, Manley PN. Promoting, Building and Sustaining a Regional Laboratory Network in a Changing Environment. Clinical Leadership Management Review; 14(5):205-10.
  • 5. Woolcott CG, Aronson KJ, Hanna WM, SenGupta SK, McCready DR, Sterns EE, Miller AB. Organochlorines and breast cancer risk by receptor status, tumour size and grade. Cancer Causes and Control; 12(5):395-404, 2001.
  • 6. Elliott BE, Meens JA, SenGupta SK, Louvard D, Arpin M. The membrane cytoskeleton crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res; 02; 7(3):R365-73, 2005.
  • 7. Hanna W, O’Malley FP, Barnes P, Berendt R, Gaboury L, Magliocco A, Pettigrew N, Robertson S, SenGupta SK, Tetu B, Thomson T. Updated recommendations from the Canadian National Consensus Meeting on HER2/neu testing in breast cancer. Current Oncology; August 2007.
  • 8. Woolcott CG, SenGupta SK, Hanna WM, Aronson K. Estrogen and progesterone receptor levels in nonneoplastic breast epithelium of breast cancer cases versus benign breast biopsy controls. BMC Cancer; 02; 8:130, 2008.
  • 9. Jefferson T, Torlakovic E, Garratt J, Miller D, Kobel M, Cooper J, Bahzad S, Pilavdzic D, O’Malley F, O’Brien A, SenGupta SK, Alport E, Tetu B, Knight B, Pettigrew N, Berendt R, Wolber R, Trotter M, Riddell R, Gaboury L, Elms F, Magliocco A, Barnes P, Gown A, Gilks. Implementation of a Canadian External Quality Assurance Program for Breast Cancer Biomarkers: an initiative of Canadian Quality Control in Immunohistochemistry (cIQc) and Canadian Association of Pathologists (CAP) National Standards Committee Immunohistochemistry. Applied Immunohistochemistry & molecular morphology; 04; 17 (5):375-82, 2009.
  • 10. Rajput AB, Hu N, Varma S, Chen C-H, Ding K, Park PC, Chapman J-A W, SenGupta SK, Madarnas Y, Elliott BE, Feilotter HE. Immunohistochemical Assessment of Expression of Centromer Protein-A (CENPA) in Human Invasive Breast Cancer. Cancers; 01; 3(4):4212-27, 2011.
  • 11. Mak H, Naba A, Varma S, Schick C, Day A, SenGupta SK, Arpin M, Elliott BE. Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells. BMC Cancer; 03; 12/82 (IF:3.01), 2012.
  • 12. Cass JD, Varma S, Day AG, Sangrar W, Rajput AB, Raptis LH, Squire J, Madarnas Y, SenGupta SK, Elliott BE. Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics. Cancers; 01; 4(3):725-42. (IF: open access), 2012.
  • 13. Skelhorne-Gross G, Reid AL, Apostoli AJ, Di Lena MA, Rubino RE, Peterson NT, Schneider M, SenGupta SK, Gonzales FJ, Nicol CJ. Stromal adipocyte PPARgamma protects against breast tumorigenesis. Carcinogenesis 05; 33(7): 1412-20. PMID:22581835, 2012.
  • 14. Hanna W, Barnes P, Berendt R, Chang M, Magliocco A, Mulligan AM, Rees H, Miller N, Elavathil L, Gilks B, Pettigrew N, Pilavdzic D, SenGupta SK. HER2 testing in breast cancer: current pathology challenges faced in Canada. Current Oncology; Volume 19, Number 6, pp. 315-323, 2012.
  • 15. Rakovitch E, Nofech-Mozes S, Narod SA, Hanna W, Thiruchelvam D, Saskin R, Taylor C, Tuck A, SenGupta SK, Elavathil L, Jani PA, Done SJ, Miller N, Youngson B, Kong I, Paszat P. Can we select individuals with low risk ductal carcinoma in situ (DCIS)? A population -based outcomes analysis? Breast Cancer Research and Treatment 03/2013.
  • 16. Grundy A, Richardson H, Burstyn I, Lohrisch C, SenGupta SK, Lai AS, Lee D, Spinelli JJ, Aronson KJ. Increased risk of breast cancer associated with long-term shift work in Canada. Occup Environ Med doi: 10.1136/oemed-101482, 2013.
  • 17. Apostoli AJ, Skelhorne-Gross GEA, Rubino RE, Peterson NT, Di LenaMA, Schneider MM, SenGupta SK, Nicol CJB. Loss of PPARy expression in mammary secretory epithelial cells creates a pro-breast tumourigenic environment. International Journal of Cancer; 08; DOI:10.1002/ijc.28432, 2013.
  • 18. Ghaffari A, Hoskin V, Szeto A, Hum M, Liaghati N, Nakatsu K, Madarnas Y, SenGupta SK, Elliott BE. A novel role for ezrin in breast cancer angio/lymphangiogenesis. Breast Cancer Res; 16(5): p. 438, 2014.
  • 19. Hanna WM, Barnes PJ, Chang MC, Gilks B, Magliocco A, Rees H, Robertson SJ, SenGupta SK, Nofech-Mozes S. HER2 Testing in Primary Breast Cancer in the Era of Standardized Testing: A Canadian Prospective Study. Journal of Clinical Oncology (JCO/2014/556092 – Epub November 10, 2014.
  • 20. Baldassare T, Watt K, Truesdell P, Meens J, Schneider MM, SenGupta SK, Craig AW. Endophilin A2 Promotes Triple-Negative Breast Cancer Cell Invasion and Tumor Metastasis. Molecular Cancer Research 03/2015; DOI:10.1158/1541-7786.MCR-14-0573.
  • 21. Apostoli AJ, Roche JM, Schneider MM, SenGupta SK, Di Lena MA, Rubino RE, Peterson NT, Nicol CJB. Opposing Roles for Mammary Epithelial-Specific PPARgamma Signaling and Activation During Breast Tumour Progression. Molecular Cancer 2015, 14:85 DOI: 10.1186/s12943-015-0347-8.
  • 22. Klein J, Kong I, Paszat L, Nofech-Mozes S, Hanna W, Thiruchelvam D, Saskin R, Done SJ, Miller N, Youngson B, Tuck A, SenGupta SK, Elavathil E, Jani PA, Slodkowska E, Rakovitch E. Close or Positive Resection Margins are Not Associated With an Increased Risk of Chest Wall Recurrence in Women with DCIS Treated by Mastectomy: A Population-Based Analysis. SpringerPlus 2015, 4:335 doi:10.1186/s40064-015-1032-5.
  • 23. Rakovitch E, Nofech-Mozes S, Hanna W, Baehner FL, Saskin R, Butler SM, Tuck A, SenGupta SK, Elavathil L, Jani PA, Bonin M, Chang MC, Slodkowska E, Anderson JM, Jamshidian F, Cherbavaz DB. A Population-Based Validation Study of the DCIS Score Predicting Recurrence Risk in Individuals Treated by Breast-Conserving Surgery Alone. Breast Cancer Research and Treatment 2015152:3464 DOI: 10.1007/s10549-015-3464-6.
  • 24. Shi J, Grundy A, Schultz J, Richardson H, Burstyn I, Lohrisch CA, SenGupta SK, Lai AS, Brooks-Wilson A, Spinelli JJ, Aronson KJ. Genetic variation in vitamin D-related genes and risk of breast cancer among women of European and East Asian descent. Tumor Biology 2015 DOI 10.1007/s13277-015-4417-8.

  •  

    CONTACT

    Tel: 613-549-6666 x4164
    Email: sengupts (at) kgh.kari.net
    Office: KGH Douglas 211


    PUBLICATIONS

    Selected Publications

     

     

     

     

    Page Created: 2012 August 25
    Page Last Updated: 2016 March 30