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Graduate Faculty Research Interests
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Faculty Research Interests

Jeremy Squire, PhD
Jeremy Squire

RESEARCH OVERVIEW

Chromosomal instability (CIN) in osteosarcoma oncogenesis”

A complex pattern of chromosomal aberrations is observed in many cancers, but the mechanisms that initiate, direct and enable this chromosomal instability (CIN) are poorly understood.  An unusually high frequency of genomic rearrangements characterizes osteosarcoma (OS) and the biological heterogeneity thus generated may provide the basis for the tumour's capacity to adapt to aggressive treatments.  An improved understanding of the molecular basis of elevated CIN in OS offers a unique opportunity to identify the early steps of aggressive cancer.  We use fluorescence in situ hybridization (FISH) to study CIN and the role of various genes (myc, RunX2, RecQL4, RB1, PTEN) in OS.

 

CONTACT

Tel: (613) 533-2345
Fax: (613) 533-2907
Email:squirej (at) queensu.ca
Office: Richardson Laboratory 201E


LABS

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PUBLICATIONS

link to PUBMED


 

 

 

 

 
 
Page Last Updated: 2013 June 11