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Graduate Faculty Research Interests
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Faculty Research Interests

Michael Rauh, MD, PhD

Michael Rauh

RESEARCH OVERVIEW

“Translational studies in myeloid blood cancers and innate immune tolerance”

Solid cancers recruit host immune cells, like macrophages, to facilitate growth yet are able to evade immune recognition.  We identified SHIP as a master regulator of the switch between anti-tumour/"killer" (M1) and pro-tumour/"healer" (M2) macrophages.  Striking parallels between the SHIP-knockout mouse phenotype and humans with blood cancers (myelodysplastic syndromes - MDS), prompted our discovery of M2-skewing in MDS.  We aim to elucidate molecular mechanisms of cancer-macrophage cross-talk and, in parallel, to harness the immunosuppressive potential of M2-macrophages to mediate Factor-VIII tolerance (seen as "foreign") in Hemophilia patients.  Approaches include high-throughput translational human pathology, mouse models, genomic and proteomic platforms.

Selected Publications:
SHIP represses the generation of alternatively activated macrophages.
Rauh MJ, Ho V, Pereira C, Sham A, Sly LM, Lam V, Huxham L, Minchinton AI, Mui A, Krystal G.  Immunity. 2005 Oct;23(4):361-74. PMID: 16226502

 

 

CONTACT

Tel: (613) 533-2818
Fax: (613) 533-2907
Email: rauhm (at) queensu.ca
Office: Richardson Laboratory 201F


LABS

> Labs coming soon.

PUBLICATIONS

link to PUBMED


 

 

 

 

 
 
Page Last Updated: 2013 June 11